The glucagon to insulin ratio was a significant predictor even after adjusting for HbA1c, LDL-C, and use of hyperlipidemia medications, and the same was true after additionally adjusting for incretins (iGLP-1, iGIP), hsCRP (cardiovascular risk factor), fibrinogen, and uric acid (Table 2). The gene discussed is GCG; the disease is hyperlipidemia.