KRAS and pancreatic adenocarcinoma: In the case of pancreatic adenocarcinoma, four conditional L2-KO and L2-KI GEMMs were generated by crossing conditional L2-KO and L2-KI alleles with two broadly studied pancreatic adenocarcinoma mice models: KPC (K-Ras+/LSL-G12D; Trp53LSL-R172H; Pdx1-Cre) or KC (K-Ras+/LSL-G12D; Pdx1-Cre) mice lines.