Interestingly, Alonso-Nocelo et al. identified that both extracellular functions (ECM remodelling and collagen crosslinking) and intracellular actions of Loxl2 (EMT induction and increased stemness of tumour cells) contribute to the metastatic effect of Loxl2 ablation and Loxl2 overexpression in the pancreatic adenocarcinoma models, respectively [39], highlighting the complex in vivo actions of Loxl2 in pancreatic tumour progression. This evidence concerns the gene LOXL2 and pancreatic adenocarcinoma.