NOTCH1 and skin neoplasm: In skin cancer cells, LOXL2 is recruited by KLF transcription factor 4 (KLF4) to the notch receptor 1 (NOTCH1) promoter, where it decreases H3K4me3 levels, thereby impairing RNA polymerase II recruitment and inhibiting NOTCH1 transcription, thus repressing epidermal differentiation [122].