This study also confirmed previous findings that implicated Loxl2 in the generation of the premetastatic niche using syngeneic breast cancer cell models [107] and the association of perinuclear LOXL2 overexpression with lung metastasis in human basal-like breast cancer, a subtype of the highly aggressive triple negative breast tumours [110]. This evidence concerns the gene LOXL2 and breast carcinoma.