In pancreatic ductal adenocarcinoma LOXL2 stabilises HIF1 by inhibiting HIF1 hydroxylation and enhancing the expression of HIF1, increasing the transcription of multiple glycolytic genes, thereby promoting aerobic glycolysis (Warburg effect) and pancreatic adenocarcinoma progression [40]. The gene discussed is HIF1A; the disease is pancreatic ductal adenocarcinoma.