In a previous meta-analysis of 32 studies with 13,367 patients, the same group reported ultrasound alone to have a satisfactory specificity of 91% (95% CI 86–94%) for T1/T2 HCC but quite a low diagnostic sensitivity of 47% (95% CI 33–61%) only, that however could be inflated to 63% (95% CI 48–75%) with the combined determination of serum AFP level [47]. Here, AFP is linked to hepatocellular carcinoma.