The association was stronger after adjustment for established T2DM risk markers including FPG, insulin, HBA1c, HOMA-IR as well as after adjusting for age (AUC = 0.74; 95% CI 0.619–0.864; p = 0.001 and AUC = 0.806; 95% CI 0.700–0.913; p > 0.001, respectively) (Figure 3), in support that the miRNA signature demonstrates good IPFD prediction when used in combination with other established markers. The gene discussed is INS; the disease is type 2 diabetes mellitus.