IL6 and neoplasm: Moreover, as the foundation of cancer, proliferative cancer cells also produce IL-6, IL-11, and other cytokines, leading to malignant proliferation and producing matrix metalloproteinases (MMPs), VEGF, and other adhesion factors, which promote angiogenesis for the nutrition supplementation of tumor cell proliferation and tumor cell circulation, as well as immune cell recruitment and activation [18,19].