Abnormal cell proliferation interacting with the immune microenvironment, angiogenesis, metabolic reprogramming, epigenetic reprogramming, the abnormal expression of the KRT17 protein, non-coding RNA, and elevated ROS are all common pathological mechanisms of psoriasis and tumors, and there are common causative genes or proteins in these shared pathological mechanisms. The gene discussed is KRT17; the disease is psoriasis.