Angiopoietin-like protein 4 (ANGPTL4) is highly expressed in the skin lesions of psoriasis patients, ANGPTL4 recombinant protein promotes psoriasis-like skin lesions in mice, and the knockout of ANGPTL4 inhibits keratinocyte growth and expresses cytokines such as IL-17, IL-6, and TNF-α [103]. The gene discussed is ANGPTL4; the disease is psoriasis.