ROS drive the development of psoriasis by regulating mitogen-activated protein kinase (MAPK), NF-κB, activator protein-1 (AP-1), and the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling pathways, which are key pathogenic signaling pathways in psoriasis [40,41]. This evidence concerns the gene WNK2 and psoriasis.