In another study, the authors found that CD226+CD8+ T cells produced a higher number of various cytokines than CD226− ones, and CD226highCD8+ T cells from SSc patients showed upregulated IL-13 production and positive correlation with the cytotoxic capacity of CD8+ T cells against human umbilical vascular endothelial cells (HUVECs) [31]. This evidence concerns the gene CD226 and systemic sclerosis.