Furthermore, the epithelial expressions of DcR2 and Ki67 were independent predictors of oral cancer development in multivariate analysis (HR = 59.7, p = 0.015 and HR = 4.14, p = 0.02, respectively), showing superior predictive value to dysplasia (HR = 4.225, p = 0.08), which highlights the limited predictability of histology in patients with OPMDs. The gene discussed is MKI67; the disease is lip and oral cavity carcinoma.