KLF4, a member of the Yamanaka factor family (OCT3/4, SOX2, KLF4, and c-MYC, collectively referred to as OSKM), is known to play a crucial role in embryonic stem cells and is also implicated in maintaining stemness and EMT processes in the context of cancer stem cell models [23,25,26]. This evidence concerns the gene KLF4 and cancer.