It was shown that CNB-001 reversed palmitic acid (PA)-induced insulin resistance by increasing the expression of the phosphorylated form of the insulin receptor (IR), insulin receptor substrate-1 (IRS-1), and protein kinase B (AKT), thereby stimulating insulin-stimulated glucose uptake in C2C12 myotubes (Table 1) [75]. The gene discussed is INS; the disease is Insulin resistance.