MMP9 and neoplasm: Grange and colleagues performed molecular characterization of microvesicles and identified specific mRNAs associated with tumor progression and metastasis, including VEGF, fibroblast growth factor-2 (FGF2), angiopoietin-1 (ANGPT1), ephrin-A3 (EFNA3), metalloproteinase (MMP)-2, and MMP9 [76].