ERCC2 and breast carcinoma: Only three MBC patients with a PV/LPV had a first-degree relative with breast or ovarian cancer history: patient #41 was identified with a RECQL4 PV/LPV and diagnosed with MBC at 77 years of age (his sister was diagnosed with breast cancer at 35 and his brother with pancreatic cancer at 79), patient #83 had a PALLD PV/LPV and was diagnosed with MBC at 59 years of age (his mother was diagnosed with breast cancer at 55) and patient #14 was an ERCC2 PV/LPV carrier and was diagnosed with MBC at 77 years of age (his mother was diagnosed with ovarian cancer at the age of 88).