Only three MBC patients with a PV/LPV had a first-degree relative with breast or ovarian cancer history: patient #41 was identified with a RECQL4 PV/LPV and diagnosed with MBC at 77 years of age (his sister was diagnosed with breast cancer at 35 and his brother with pancreatic cancer at 79), patient #83 had a PALLD PV/LPV and was diagnosed with MBC at 59 years of age (his mother was diagnosed with breast cancer at 55) and patient #14 was an ERCC2 PV/LPV carrier and was diagnosed with MBC at 77 years of age (his mother was diagnosed with ovarian cancer at the age of 88). Here, ERCC2 is linked to pancreatic neoplasm.