Genetic testing is currently performed on a consensus panel of predisposition genes, initially BRCA1/BRCA2/PALB2 genes, and now an HBOC (hereditary breast and ovarian cancer) panel including BRCA1, BRCA2, PALB2, TP53, CDH1, PTEN, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2 and EPCAM genes. This evidence concerns the gene PALB2 and Hereditary breast and ovarian cancer syndrome.