BRCA1 and Hereditary breast and ovarian cancer syndrome: Genetic testing is currently performed on a consensus panel of predisposition genes, initially BRCA1/BRCA2/PALB2 genes, and now an HBOC (hereditary breast and ovarian cancer) panel including BRCA1, BRCA2, PALB2, TP53, CDH1, PTEN, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2 and EPCAM genes.