PCNA and cancer: The treatment of cancer the cell lines with BAPPN significantly increased the protein expression of caspase-3 and P53 in HepG2 cells (Figure 7A,B) and HCT-116 cells (Figure 8A,B) compared to DMSO-treated control cells; however, the treatment downregulated PCNA and Ki67 protein expression in HepG2 cells (Figure 7C,D) and HCT-116 cells (Figure 8C,D) in comparison to DMSO-treated control cells.