Furthermore, the preliminary data from our laboratory show that in STZ-induced T1DM, 8-OH-DPAT reverses the decrease in anti-inflammatory mediators, CD206, tumor growth factor-beta and interleukin-10, and antioxidant markers, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and superoxide dismutase-2. This evidence concerns the gene IL10 and type 1 diabetes mellitus.