Remarkably, treatment with 8-OH-DPAT significantly downregulated the expression of these enzymes in LSSC tissues, not only threefold relative to that in tissues from T1DM animals but also to levels below that observed in control animals (50–60% less, Figure 7B, Ido1: F: 32.6, p = 0.0006; Ido2: F: 19.6, p = 0.0023; Tdo: F: 29.9, p = 0.0008). The gene discussed is IDO1; the disease is type 1 diabetes mellitus.