In humans, this epitope is encoded by either FUT1 (fucosyltransferase 1, in blood) or FUT2 (epithelial cells on mucosal surfaces), which is required for the final step of the synthesis of soluble A and B antigens [50], but, interestingly, also mediates diverse biologic processes, such as angiogenesis, macrophage polarization, keratinocyte migration,, and cancer cell survival [51,52]. The gene discussed is FUT2; the disease is cancer.