The IRP(1) activity of AML blasts, excluding secondary AML, is approximately three times larger than that of non-leukemic CD34+ cells (Welch’s t-test p = 0.012) (Figure 4B), which agrees with the increased TFRC mRNA (Figure 2E) that is stabilized by IRP activity. This evidence concerns the gene WNT2 and acute myeloid leukemia.