In a study in which the insulin resistance caused by PC was investigated, PC-derived miRNAs, such as miR-666-3p, miR-540-3p, miR-125b-5p, miR-450b-3p, miR-883b-5p, 666-3p, miR-450b-3p, and miR-151-3p, were found to be capable of inducing insulin resistance in the skeletal muscle cells through the PI3K/Akt/FoxO1 signaling pathways [27]. The gene discussed is FOXO1; the disease is pachyonychia congenita.