Supportive of the cancer relevance of potential PLK1-enhanced miR biogenesis, the most robustly PLK1 inhibitor-downregulated miRs, miR-93-3p, miR-21-5p and miR-17-5p, or their cluster-partner miRs were amongst the top ten PLK1-correlated miRs in 12, 8 and 15 of the 33 cancers of the TCGA data set, respectively (Figure S5). Here, PLK1 is linked to cancer.