CD80 and breast cancer: Cell cycle blocking.Malignancy growth suppressing.↓ Iron levels, and mitogen-activated protein kinases (MAPK/P38) by ↓ iron levels and MAPK/P38.Inhibition of differentiation complex (CD4 and CD80) expression.↓ Transformation of growth factor beta interleukin-6, interferon-gamma, interleukin-2, and vascular endothelial growth factor (VEGF) expression in the signaling pathway.Modulation of gene expression of CD8 and the natural killer group 2D.↓ Proliferation of breast cancer cells.