While PDGFRα, which is the second most amplified receptor in glioblastoma after EGFR, is primarily upregulated in the proneural subtype, PDGFRβ is preferentially expressed in glioma stem cells (GSCs), where it regulates the level of stem cell markers, like SOX2 [4,123]. The gene discussed is PDGFRA; the disease is glioblastoma.