CASP1 and breast cancer: After 24 h of treating PBMCs isolated from HR+ BC patients with 20 μM TQ, an initial non-significant upregulation was observed in caspase-1, followed by a significant dampening in its expression at 50 μM (* p = 0.0195); finally, it was significantly upregulated at 100 μM (** p = 0.0013) (one-way ANOVA, *** p = 0.0002) (Figure 3A).