HSPA5 and breast cancer: The current study showed that TQ was a successful inhibitor of CALR expression in PBMCs of HR+ and TNBC patients in various concentrations and durations, as shown in Figure 8A. Although this is the first study to report the inhibitory effect of TQ on CALR in general and specifically in BC, the literature reported that TQ inhibited the expression of GRP78 in a rat model in vivo [124].