This periodontitis-associated mixture of gram-negative bacteria includes P. gingivalis [45] and associates with the presence of IL1B+3954(T) and moderate or severe periodontitis [32]; (c) Unlike weak GCF exudation, strong GCF exudation expels bacteria efficiently from gingival crevices [46] which assists oral hygiene in retarding ‘red’ complex and periodontitis development. The gene discussed is IL1B; the disease is periodontitis.