JARID2 (OMIM; #601594) haploinsufficiency (DIDDF, OMIM; #620098) leads to a clinically distinct neurodevelopmental syndrome characterized by intellectual disability (ID), developmental delay (DD), autistic features, behavior abnormalities, cognitive impairment, hypotonia, and dysmorphic features such as high anterior hairline, deeply set eyes, depressed nasal bridge, full lips, broad forehead, and bulbous nasal tip [1,2]. This evidence concerns the gene JARID2 and Global developmental delay.