A tree-and-leaf plot showed that the JARID2 genome-wide DNA methylation change is most closely related to the DNA methylation changes of Coffin–Siris syndrome-9 (CSS9; SOX11), myopathy, lactic acidosis, and sideroblastic anemia 2 (MLASA2; YARS2) and Lysine-demethylase 2B (KDM2B) (Figure 5B). This evidence concerns the gene KDM2B and intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism.