People with T2D and microalbuminuria show a rise in renal IGF-1 levels, IGFBP-3 protease activity, and the increased excretion of bioactive growth hormone, IGF-1, and IGFBP-3 proteins that indicate a defective growth hormone/IGF/IGFBP system [32]. The gene discussed is IGFBP3; the disease is type 2 diabetes mellitus.