Similarly, there was a positive correlation between circulating ANGPTL8 and serum creatinine in people with DN (r = 0.37, p = 0.007, Figure 3A), while ANGPTL8 was negatively correlated with both eGFR (r = −0.44, p = 0.002, Figure 3B) and urine creatinine (r = −0.407, p = 0.004, Figure 3C). Here, ANGPTL8 is linked to liver dysplastic nodule.