On the other hand, people with T2D presented both IGFBP4 (β = 0.624, p = 0.006) and VLDL (β = 0.413, p = 0.009) as predictors for an increase in circulating ANGPTL8 (Table 4), while LDL acted as a negative predictor of ANGPTL8 increase in people with T2D (β = −0.355, p = 0.023, Table 4). Here, IGFBP4 is linked to type 2 diabetes mellitus.