Among studies that defined AD based on core CSF biomarkers (amyloid, t-tau, and p-tau), Sathe et al. presented a deep pilot CSF analysis from five AD subjects and five controls and identified 2327 proteins with 139 DEPs, including MAPT, NPTX2, VGF, GFAP, NCAM1, PKM, and YWHAG [7]. This evidence concerns the gene PKM and Alzheimer disease.