In the AD group, the levels of eight proteins—HV316 (gene name: IGHV3-16), PDCD5 (PDCD5), H2B1K (H2BC12), CAH11 (CA11), ACBP (DBI), CH60 (HSPD1), PPIC (PPIC), and MFAP5 (MFAP5)] were elevated, while 60 proteins [the top nine being: MYP2 (PMP2), AT1B1 (ATP1B1), TPM3 (TPM3), LIGO3 (LIGO3), SRGN (SRGN), MCP (CD46), PRDX3 (PRDX3), CAZA2 (CAPZA2), and ZNF84 (ZNF84)—were downregulated compared with the NC group. The gene discussed is PPIC; the disease is Alzheimer disease.