Higginbotham et al. identified 225 downregulated proteins and 303 upregulated proteins in 20 AD cases compared with 20 controls, including MAPT, NEFL, GAP43, FABP3, CHI3L1, NRGN, VGF, GDI1, and SMOC1 [9]. This evidence concerns the gene VGF and Alzheimer disease.