We further investigated mRNA extracts from OBCs of the slower degenerating C3H/HeOuJ_Opto-mGluR6 rd1 (C3H/HeOuJ rd1) retina [36] and found the same upregulation of Kv1.3 (p105: 0.61 ± 0.071%; p210: 1.31 ± 0.057%, ** p = 0.015) (Supplementary Figure S1), confirming that Kv1.3 upregulation is a common denominator of retinal degeneration and not mouse-line specific. This evidence concerns the gene PDE6B and retinal degeneration.