LDLR and obesity due to melanocortin 4 receptor deficiency: Supplementation of C5 to an HFD increases the abundance of haem biosynthesis and reductive acetyl coenzyme A pathways, supplementation of C5 to db/db mice (who develop obesity as mice fed an HFD do) decreases the mannan degradation pathway, supplementation of C5 to LDLR (−/−) mice (who do not develop obesity) increases the pathways of methanogenesis (superpathway of sulphur oxidation and pathway of factor 420 biosynthesis), which were decreased in mice fed an HFD.