Mice of C57BL/6 line were fed a regular chow diet (RCD) with or without C5 supplementation and a high-fat diet (HFD) with or without C5 supplementation, whereas LDLR (−/−) and db/db mice (that were used for the modelling of atherosclerosis and obesity) were fed RCD with or without C5 supplementation only (Figure 2). Here, LDLR is linked to atherosclerosis.