The HFD decreased mRNA expression of IL-17A, IL-17F, IL-22, TNF-α, IL-1β, CXCL1, CXCL2, and keratin 16, and increased mRNA expression of TGF-β1 and CDKN1A in imiquimod-induced dermatitis. The gene discussed is CXCL2; the disease is dermatitis.