The effects of the HFD should further be evaluated in the other psoriasis models, such as human non-lesional psoriasis skin-transplanted model (SCID-hu), global gene-manipulated (B27/hβ2m-transgenic rat, IL1rn−/− mice), keratinocyte-specific gene-manipulated (K14-VEGF, K5.Stat3C), intradermal IL-23-injected or IL-23 mini-circle DNA-delivered mice, or autoantigen-recognizing T cell-transferred Rag−/− mice (Dsg3H1) [22], or UVB photodermatitis rats [61]. Here, IL1RN is linked to psoriasis.