The most recent study is a double-blind placebo-controlled RCT [45] that demonstrated no difference in the incidence of moderate-to-severe OHSS between low-dose aspirin (100 mg daily) vs. the placebo in 214 infertile PCOS patients scheduled for GnRH-a IVF programs (38/109 (34.9%) vs. 32/105 (30.5), respectively; p = 0.494). This evidence concerns the gene GNRH1 and Infertility.