This finding aligns with earlier studies wherein C21 demonstrated the restoration of blood pressure in various hypertensive models, including testosterone-induced hypertension in pregnant Sprague Dawley rats [47], Ang II-induced hypertension in non-pregnant female Sprague Dawley rats [59], and salt-induced hypertension in male obese Zucker rats [60]. The gene discussed is AGT; the disease is Hypertension.