In this family, additional disorders that may be associated with FVIII/VWF increase were reported, including the following: obesity (II-8, II-3, II-9), overweight (II-2, II-5, III-5), diabetes (II-8, II-2, II-3, II-5), dyslipidemia (II-8), atrial fibrillation (II-3), tumor and hypertension (II-5) (Table 1). This evidence concerns the gene F8 and obesity due to melanocortin 4 receptor deficiency.