VWF and Rare hereditary thrombophilia: Inherited risk factors that cause a hypercoagulable state, commonly known as thrombophilia abnormalities, include factor V Leiden (rs6025), the prothrombin variant rs1799963, and deficiencies of the natural anticoagulants antithrombin, protein C, and protein S. In addition, several genes mainly related to erythrocytes, platelets, and inflammation, but also including F8 and VWF, that code for FVIII and VWF have been associated with the risk of VTE in meta-analyses of genome-wide association studies [10,11].