Su et al. [160] demonstrated increased levels of EV-associated tissue factor (TF), coatomer protein complex beta subunit (COPB2), interleukin-18 receptor 1 (IL-18R1) activated caspase 3, and domain mixed-origin kinase-like (MLKL) with risk of microthrombosis, malignant disease progression, and hospital stay in patients with COVID-19. Here, IL18R1 is linked to COVID-19.