Moreover, the combination of p-Tau and neurofilament light chain (NfL) provided satisfactory results for early AD diagnosis [20,21]; in addition, a previously developed model including Aβ42, Aβ42/Aβ40 ratio, t-Tau, p-Tau181, and NfL [22] showed promising results in the early diagnosis of AD. This evidence concerns the gene NEFL and Alzheimer disease.