Indeed, a cytokine storm had been observed in severely ill COVID-19 patients, and most of these patients exhibited markedly increased serum levels of proinflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-α), GM-CSF, and IL-1β [1,3,6,7,8]. The gene discussed is IL1B; the disease is COVID-19.