In renal fibrosis, the lymphangiogenesis-activated inflammatory response promotes the progression of renal fibrosis, and hyperplasia LECs of the kidney and the corresponding draining lymph node upregulate the chemokine CCL21, induce infiltration of a large number of CCR7 receptor-expressing lymphocytes, macrophages and dendritic cells into the kidney and draining lymph nodes, and expand the inflammatory response and promote fibrosis [5]. This evidence concerns the gene CCL21 and renal fibrosis.