CASP3 and mucopolysaccharidosis: Moreover, during the staurosporine-mediated induction of apoptosis, the levels of caspase-3 (cleaved at Asp175), caspase-6 (cleaved at Asp162), caspase-7 (cleaved at Asp198), and PAPR (cleaved at Asp214) were higher in MPS IVA and MPS IVB than in HDFa (Figure 2).