Namely, the expression of genes coding for apoptotic proteins (TNF-R1, caspase-3, caspase-9, caspase-11) was enhanced in the brains of MPS VII mice [59], and apoptosis stimulation was evident also in the resting zone of the growth plate, contributing to the pathology of bones and cartilages [60]. Here, TNFRSF1A is linked to mucopolysaccharidosis type 7.