Since MPS IV is an example of a genetic disease, and any changes are expected to be mainly due to internal perturbations in cellular structures and/or processes, we focused on the latter pathway of apoptosis, and thus, on determining cytochrome c release and activation of caspase-9, and then on levels of executive caspases (3, 6, and 7). The gene discussed is CASP9; the disease is hereditary disease.