Among the multiple genetic loci that have been suggested to contribute to SLE susceptibility, the locus 12q24, which harbors the P2RX7 gene, has been proposed to be involved in the propensity to develop the disease in Hispanic and European American families [66], while some P2RX7 polymorphisms were identified as possible inducers of SLE susceptibility in the Chinese population [67] (Table 1). This evidence concerns the gene P2RX7 and systemic lupus erythematosus.