The ALS cell mutation conduction model downregulates the cystine/glutamate antiporter (SLC7A11) and glutathione peroxidase 4 (GPX4), leading to motor neuron ferroptosis, whereas the activation of nuclear factor erythroid 2-related factor 2 (NRF2) attenuates motor neuron ferroptosis and exerts neuroprotective effects in vitro and in vivo [20,21]. The gene discussed is NFE2L2; the disease is amyotrophic lateral sclerosis.