GPX4 and Alzheimer disease: Furthermore, in male APP/PS1 mice, N2a cells exposed to Aβ42, erastin-stimulated HT22 cells (a cellular model of desferrioxic anemia), and LPS-induced BV2 cells in these models, forsythoside A attenuated AD pathology by inhibiting ferroptosis-response-mediated neuroinflammation via the Nrf2/GPX4 axis [136].