GPX4 and Parkinson disease: Using a model in which α-synuclein, DA, and iron act synergistically to exacerbate ferroptosis in the midbrain nucleus, which leads to a loss of dopaminergic neurons during PD, this study introduces a novel pathway in which iron-induced DA oxidation isolates GPX4 through the ubiquitin–proteasome system to degrade it, thereby disrupting GPX4 function and leading to lipid peroxidation, and, ultimately, ferroptosis [22].