In addition, the overexpression of CXCL8 in ovarian cancer cells activates mitogen-activated protein kinase (MAPK) signaling and signal transducer activator of transcription 3 (STAT3), which in turn increases the expression of VEGF and decreases the level of thrombospondin-1 (TSP-1). The gene discussed is THBS1; the disease is ovarian carcinoma.