Our findings regarding L169P VHL corroborates a prior study by Rechsteiner et al. [4] that used an HIFαs-GFP degradation reporter assay in MEF (mouse embryonic fibroblast) cells to assess the E3 ligase function of missense variants of VHL, identified in ccRCC tumors. Here, VHL is linked to nonpapillary renal cell carcinoma.