Four proteins were found to be regulated in the same manner in the three ST1926-treated GBM cell lines: DNA topoisomerase 2-alpha (TOP2A), Sequestosome-1/p62 (SQSTM1), Tubulin alpha-4A chain (TUBA4A), and Collagen alpha-1(VI) chain (COL6A1). The gene discussed is TOP2A; the disease is glioblastoma.