A comparative analysis of BCC-associated CAFs and fibroblasts derived from normal skin from the same patients, evidenced overexpression of some proteins previously associated with CAF phenotypes and seven BCC-stroma specific proteins (CTSK, cathepsin K, MGP, matrix Gla-protein, CLIP, cartilage intermediate layer protein, DPT dermatopontin, SFRP2, secreted frizzled-related protein 2, PDGFRL, platelet-derived growth factor receptor-like protein, and ANGPTL2, angiopoietin-related protein 2) [309]. This evidence concerns the gene SFRP2 and skin basal cell carcinoma.