WNK2 and neoplasm: For example, melanoma synthesizes FGFs, that due to the frequent constitutive activation of the downstream mitogen-activated protein kinase-extracellular signal-regulated kinase (MAPK-ERK) signaling pathway, do not confer a specific advantage to tumor cells but can influence the neighboring cells in the tumor niche, such as endothelial cells and fibroblasts contributing to intratumoral angiogenesis and the development of resistance to therapeutics [145].