According to the Western blotting results (Figure 3) and the quantification of band intensities (Supplementary Figure S3), malignant PF samples M9 and M12 increased the phosphorylation of P-AKT S473, P-AKT T308, and P-p42/44 MAPK T202/Y204, or these phosphorylation events occurred earlier, compared to the benign PF samples. Here, AKT1 is linked to pemphigus foliaceus.