KRAS and neoplasm: Given that morphology and molecular features are reliable to unify the correct CRC categorization, four consensus molecular subtypes (CMSs) were proposed by the Colorectal Cancer Subtyping Consortium: CMS 1 (representing 14% of CRC) as a kind of microsatellite instability (MSI)-high CRC (II), CMS 2 (37% of CRC) with extensive activation of WNT and MYC signaling pathways, CMS 3 (13% of CRC), which exhibits mostly KRAS-activating mutations, and CMS 4 (23% of all CRCs) as a type of tumor with remarkable stromal invasion related to epithelial mesenchymal transition (EMT).