CELSR1 and polycystic kidney disease: Additionally, Wnt/PCP is considered a factor involved in polycystic kidney disease development through gene mutations such as CELSR1, CELSR2, CELSR3 (representing cadherin EGF LAG seven-pass G-type receptor 1/2/3), VANGL1 and VANGL2 (representing Vang-like protein 1/2).