Regarding the prevalence of preoperative hypopituitarism, despite the larger tumor size of GH–PRL-secreting PitNETs described in some series [4,95,104], no significant differences in the rates of hypoadrenalism, hypothyroidism and hypogonadism have been detected across the different subtypes in some series [3]; other authors did not describe this aspect [95,104]. Here, GH1 is linked to neoplasm.