Nevertheless, more recent studies did not detect differences in age presentation of the acromegaly across the different GH-secreting PitNETs subtypes [4]; neither were differences found when comparing patients with positive staining only for GH and with positive staining for both PRL and GH [95] nor when comparing patients with normoprolactinemia and patients with high PRL levels [105]. This evidence concerns the gene GH1 and acromegaly.