To determine how LPJZ-658 prevented hepatic fibrosis in NASH mice, we examined the expression of transforming growth factor-β (TGF-β), a master regulator of fibrogenesis, and targeted genes such as collagen 1 alpha 1 (Col1a1) in the liver (Figure 3C,D). Here, COL1A1 is linked to metabolic dysfunction-associated steatohepatitis.