To determine how LPJZ-658 prevented hepatic fibrosis in NASH mice, we examined the expression of transforming growth factor-β (TGF-β), a master regulator of fibrogenesis, and targeted genes such as collagen 1 alpha 1 (Col1a1) in the liver (Figure 3C,D). The gene discussed is COL1A1; the disease is Hepatic fibrosis.