Moreover, hepatic fatty acid synthesis-related genes (Fatty Acid Synthase [FAS], Stearoyl-CoA desaturase 1 [SCD1], cluster of differentiation 36 [CD36], sirtuins 1 [Sirt1], sterol-regulatory element-binding protein 1c [SREBP1c], and carbohydrate-responsive element-binding protein [ChREBP]), mRNA, and/or protein levels were significantly increased in NASH mice compared to CON mice, which strikingly decreased with LPJZ-658 treatment in NASH + LPJZ-658 mice. Here, SIRT1 is linked to metabolic dysfunction-associated steatohepatitis.