CD36 and steatosis: Moreover, LPJZ-658 inhibited fatty acid uptake and synthesis-related genes [42,43] FAS, SCD1, CD36, SREBP1c, ChREBP mRNA expression promoted lipid β-oxidation genes and the related genes’ PGC-1α and CPT1 mRNA expression, suggesting that LPJZ-658 may decreased hepatic accumulation and steatosis by inhibiting the de novo synthesis and uptake of fatty acids while accelerating fatty acid β-oxidation.