COX4I1 and hepatocellular carcinoma: We observed a parallel trend between the amount of cytochrome c oxidase subunit IV (COX IV) and IC-malate, which indicates a change in mitochondrial activity in HLE and LX2 cells after treatment with conditioned media (Figure 13a,b) and highlights potential symbiotic rewiring in hepatoma and fibroblasts induced by each other’s media.