In the LPS + HP group, domination of M1, the lowest survivin level, positive chitin-like polysaccharide and increasing expression of short-chain proteins cleaved from long APP in the hippocampus and GFAP in both the hippocampus and the cortex characterised the pro-neurodegenerative milieu with a behavioural pattern of depression in mice. Here, GFAP is linked to major depressive disorder.