Significantly different ACE2 serum protein levels in patients with different COVID-19 severity were observed only in HQM patients with high blood pressure (absent (n = 150), 9.09 [7.83; 9.71] vs. present (n = 50), 9.40 [8.84; 10.70]) and CVDs (absent (n = 119), 9.09 [8.36; 9.84] vs. present (n = 36), 9.53 [8.36; 10.44]). This evidence concerns the gene ACE2 and hypertensive disorder.