STAT3 can also cooperate with NFκB to enhance the stemness of cancer cells, and it can also trap the RELA (p. 65) subunit of NFκB in the nucleus, thereby regulating the expression of oncogenic and inflammatory genes that include inflammatory mediators such as IL-6, which can facilitate the establishment of a “feed forward” loop of STAT3 activation [109,118,119,121,122,123,124,129,130,131,132,133,134,135,136,137,138]. This evidence concerns the gene IL6 and cancer.